Selectins, activated leukocyte cell adhesion molecule, and platelet endothelial cell adhesion molecule-1 tissue levels in patients with low- and high-grade gliomas Düşük-dereceli ve yüksek-dereceli gliomlu hastaların dokularında selektin, lökosit hücre adezyon molekülü ve platelet endotel hücre adezyon molekülü-1 seviyeleri
Journal of Neurological Sciences, cilt.34, sa.1, ss.42-51, 2017 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 1
- Basım Tarihi: 2017
- Dergi Adı: Journal of Neurological Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.42-51
- Anahtar Kelimeler: Adhesion molecules, ALCAM, Brain tumors, PECAM-1, Selectin
- Kırklareli Üniversitesi Adresli: Evet
Özet
Background: Adhesion molecules play an important role(s) in inflammation, tumor cell progression and invasion. Here we investigated tissue levels of selectins (E-, L-, and P-selectins), activated leukocyte cell adhesion molecules (ALCAM), and platelet endothelial cell adhesion molecules-1 (PECAM-1) in a series of patients with glial tumors and controls. Methods: A total of 39 patients, 19 with low-grade gliomas and 20 with high-grade gliomas, and 15 deceased controls who underwent autopsy after trauma were included. Adhesion molecules were measured using enzyme-linked immunosorbent assay and the results were analyzed. Results: Statistically significant differences were found between the patients and controls regarding every molecule (p<0.05). Furthermore, significantly higher levels were found in patients with high-grade gliomas compared with those with low-grade gliomas. Conclusion: These results suggest that adhesion molecules may have a role in glioma formation and targeted therapies could help in the treatment of these devastating brain tumors.