Anemia and PET imaging
Clinical and Translational Imaging, cilt.9, sa.5, ss.499-509, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 9 Sayı: 5
- Basım Tarihi: 2021
- Doi Numarası: 10.1007/s40336-021-00442-z
- Dergi Adı: Clinical and Translational Imaging
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.499-509
- Anahtar Kelimeler: Anemia, PET, FDG, FLT, Fe-52
- Kırklareli Üniversitesi Adresli: Hayır
Özet
Aim: Anemia is a blood disorder characterized by reduced Hemoglobin concentration and/or red blood cells numbers. Most common causes of anemia are iron deficiency anemia and anemia of chronic disease (anemia of chronic inflammation), but there is a long list of conditions which cause anemia. Bone marrow (BM), spleen, and liver are the main organs but various other tissues are also involved depending on the type of anemia. In this article, we aimed to review the role of PET imaging in anemia. Methods: Normal BM, typical and atypical forms of hematopoiesis, pathogenesis of various forms of anemia, and PET findings in anemia with various radiotracers such as 18F-fluorodeoxyglucose, 18F-fluorothymidine, 52Fe compounds and 18F-sodium fluoride were reviewed. Results: In cases with anemia PET can help in determining the extent of BM expansion, distribution of BM, detecting proliferative activity of BM and BM islands in acellular BM on iliac biopsy, guiding BM biopsies, detecting typical or atypical extramedullary hematopoiesis, acute BM infarctions and various other complications such as osteomyelitis, cerebral infarction and infarction in various other tissues. Anemia-related PET findings can mimic tumor/metastases. Conclusion: PET imaging is useful for assessing various types of anemia. It is also important to be aware of anemia-related PET findings to avoid mistaking them for malignancy or metastases.