Retrospective analysis of bacterial agents in central nervous system infections and antibiotic resistance: A nine years evaluation at a university hospital
Journal of Experimental and Clinical Medicine (Turkey), cilt.40, sa.2, ss.307-311, 2023 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.52142/omujecm.40.2.20
- Dergi Adı: Journal of Experimental and Clinical Medicine (Turkey)
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier
- Sayfa Sayıları: ss.307-311
- Anahtar Kelimeler: antimicrobial resistance, bacterial agents, central nervous system, cerebrospinal fluid, infection
- Kırklareli Üniversitesi Adresli: Evet
Özet
The follow-up of bacterial agents and antibiotic resistance profiles that cause central nervous system (CNS) infections has guided the choice of life-saving empirical treatment against these infections. This study aimed to evaluate the bacterial agents isolated from cerebrospinal fluid (CSF) samples and their antibiotic susceptibility for nine years with the suspicion of CNS infection. We retrospectively analyzed the results of the patients sent CSF samples for bacteriological diagnosis with the suspicion of CNS infection between August 2012 and April 2021. The isolated bacterial species were identified using conventional methods, biochemical tests, and various commercial identification systems. Microorganisms were isolated in 121 (14.85%) of the 815 CSF samples examined. The most commonly isolated agents are methicillin-resistant coagulase-negative Staphylococci (n: 59; 48.76%) among Gram-positive and Klebsiella spp. (n: 12; 9.92%) among Gram-negative. The follow-up of bacteria isolated from CNS infections, which can progress rapidly and cause serious complications, and the changes in antibiotic susceptibility over the years are known as a guide in regulating appropriate treatment. Our results may contribute to the selection of antibiotics that can be used especially in cases where urgent empirical treatment is required.