Inhibition of mammalian carbonic anhydrase isoforms I, II and Vi with thiamine and thiamine-like molecules
Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.28, sa.2, ss.316-319, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2011
- Doi Numarası: 10.3109/14756366.2011.637200
- Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.316-319
- Anahtar Kelimeler: Carbonic anhydrase, thiamine, inhibition
- Kırklareli Üniversitesi Adresli: Evet
Özet
Here we determined the in vitro inhibitory effects of 5-(2-hydroxyethyl)-3,4-dimethylthiazolium iodide (1), 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (2) and thiamine (3) on human erythrocyte carbonic anhydrase I, II isozymes (hCA i and hCA II) and secreted isoenzyme CA Vi. Ki values ranged from 0.38 to 2.27 μM for hCA I, 0.085 to 0.784 μM for hCA II and 0.062 to 0.593 μM for hCA VI, respectively. The compounds displayed relatively strong actions on hCA II, in the same range as the clinically used sulfonamidesethoxzolamide, zonisamide and acetazolamide.