Novel water soluble 7-oxy-4-(pyridine-3-yl)coumarin substituted phthalocyanines as potential photosensitizers for photodynamic therapy
Inorganica Chimica Acta, cilt.494, ss.30-41, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 494
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.ica.2019.05.004
- Dergi Adı: Inorganica Chimica Acta
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.30-41
- Anahtar Kelimeler: Coumarin (2H-chromen-2-one), Phthalocyanine, Water soluble, Zinc, Indium, Magnesium
- Kırklareli Üniversitesi Adresli: Evet
Özet
The new phthalonitriles (1 and 2) and zinc, indium, magnesium metalled tetrasubstituted phthalocyanines bearing 7-oxy-4-(pyridine-3-yl)coumarin substituents in the peripheral (1a-c)/non-peripheral (2a-c) positions were prepared for the develop novel water-soluble phthalocyanines. Newly synthesized phthalocyanines were turned into highly water-soluble quaternized ionic counterparts (1d-f, 2d-f). The effects of metal ions and substituents in the phthalocyanine ring on spectral, photochemical and photophysical properties of newly prepared phthalocyanines were examined of the non-ionic phthalocyanines (1a-c, 2a-c) in DMF and quaternized ionic phthalocyanines (1d-f, 2d-f) in both of DMF and water. Water-soluble peripheral substituted indium (III) (1e) and non-peripherally substituted zinc (II) (2d), indium (III) (2e) phthalocyanines showed good singlet oxygen formation that performed them as a highly promising photosensitizers for photodynamic therapies.