Aldosterone synthase CYP11B2 gene promoter polymorphism in a turkish population with chronic kidney disease
Iranian Journal of Kidney Diseases, cilt.9, sa.3, ss.209-214, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 3
- Basım Tarihi: 2015
- Dergi Adı: Iranian Journal of Kidney Diseases
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.209-214
- Anahtar Kelimeler: Aldosterone synthase gene, Chronic kidney disease, Gene polymorphism
- Kırklareli Üniversitesi Adresli: Hayır
Özet
Introduction. It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C > T) influences the aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. We aimed to investigate whether there is an effect of CYP11B2 -344 C > T polymorphism on the development of CKD in a Turkish population. Material and Methods. A total of 240 patients with stage 5 CKD and 240 age- and sex-matched healthy individuals were included in the study. Genotyping of CYP11B2 gene -344 T > C promoter polymorphism was carried out using polymerase chain reaction and restriction fragment length polymorphism methods. Results. No significant differences were found in the genotype distribution of CYP11B2 -344 C > T polymorphism between the patients and controls; however, -344 C > T polymorphism was significantly more frequent among the CKD patients with diabetes mellitus as compared to those with it (P =.02). Diabetic CKD patients with TC genotype had a 2-fold increased risk for development of the disease than the CKD patients without diabetes mellitus (odds ratio, 2.21; 95% confidence interval, 1.04 to 4.67). Conclusions. Our study suggests that the CYP11B2 gene -344 C > T polymorphism may have an effect on the development of CKD in diabetic patients.