Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human biliverdin reductase
Clinical Neurology and Neurosurgery, cilt.158, ss.72-76, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 158
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.clineuro.2017.05.003
- Dergi Adı: Clinical Neurology and Neurosurgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.72-76
- Anahtar Kelimeler: Glioma, Lipid peroxidation, Meningioma, Protein oxidation, ROS
- Kırklareli Üniversitesi Adresli: Evet
Özet
Objective To assess oxidant and antioxidant status in patients with common brain tumors; namely meningiomas, low-grade gliomas (LGG) and high-grade gliomas (HGG) and to compare with normal brain tissues. Patients and methods Almost nine biomarkers were measured in 59 brain tumors obtained during surgery and 15 normal brain tissues that were collected during autopsy. Results were compared between two groups. Results In general, protein oxidation and lipid peroxidation increased while antioxidant capacity decreased significantly in tumors compared to the controls (p < 0.05) and higher the grade of the tumor, higher the levels of oxidation and lower the anti-oxidation. Conclusions Reactive oxygen species may play a crucial role in the pathogenesis of these common brain tumors. As the processes at the molecular level understood, targeted-treatment adjunct to surgical removal will be possible to cope with these devastating brain tumors.