Effect of tumour necrosis factor-alpha and interleukin-6 promoter polymorphisms on course of Crimean-Congo hemorrhagic fever in Turkish patients
Journal of Vector Borne Diseases, cilt.52, sa.1, ss.30-35, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52 Sayı: 1
- Basım Tarihi: 2015
- Dergi Adı: Journal of Vector Borne Diseases
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.30-35
- Anahtar Kelimeler: Crimean-Congo hemorrhagic fever (CCHF), IL-6, polymorphism, TNF-alpha
- Kırklareli Üniversitesi Adresli: Hayır
Özet
Objective: In this case-control study, we investigated whether IL-6 (-174G/C) and TNF-α (-308G/A) gene polymorphisms affect the clinical course and outcome of CCHF. Methods: Total 150 patients with CCHF and 170 controls were examined in this study. Genotyping of these polymorphisms were performed by PCR-RFLP methods. Results: We found no statistically significant differences in genotype and allele frequencies of these polymorphisms between patients and controls [(χ 2 = 1.31, p = 0.51 for TNF-α) and (χ2 = 2.61, p = 0.27 for IL-6)]. Either TNF-α AA or IL-6 CC genotypes in dead cases were not observed in this study. Frequency of heterozygous genotypes in both IL-6 (GC) and TNF-α (GA) was higher in dead patients than living patients. However, the difference was not statistically significant. A significant difference was found in AST levels and INR when compared to patients with CCHF who died and who survived [OR = 13.9 (95% CI = 1.79–107) for INR, p = 0.01] and [OR = 23.3 (95% CI = 3.62–149) for AST, p = 0.001], respectively. Conclusion: We did not find a significant association of IL-6 -174G/C and TNF-α -308G/A polymorphisms on the prognosis of CCHF and mortality in this study. We suggest that AST and INR may be important biomarkers for determining the risk of severity and death as a result of infection with Crimean-Congo hemorrhagic fever virus (CCHFV).